Biochemistry, polymers, and technology

 Biochemistry, polymers, and technology

Organic chemistry, of course, looks not only in the direction of physics and physical chemistry but also, and even more essentially, in the direction of biology. Biochemistry began with studies of substances derived from plants and animals. By about 1800 many such substances were known, and chemistry had begun to assist physiology in understanding biological function. The nature of the principal chemical categories of foods—proteins, lipids, and carbohydrates—began to be studied in the first half of the century. By the end of the century, the role of enzymes as organic catalysts was clarified, and amino acids were perceived as constituents of proteins. The brilliant German chemist Emil Fischer determined the nature and structure of many carbohydrates and proteins. The announcement of the discovery (1912) of vitamins, independently by the Polish-born American biochemist Casimir Funk and the British biochemist Frederick Hopkins, precipitated a revolution in both biochemistry and human nutrition. Gradually, the details of intermediary metabolism—the way the body uses nutrient substances for energy, growth, and tissue repair—were unraveled. Perhaps the most representative example of this kind of work was the German-born British biochemist Hans Krebs’s establishment of the tricarboxylic acid cycle, or Krebs cycle, in the 1930s.

But the most dramatic discovery in the history of 20th-century biochemistry was surely the structure of DNA (deoxyribonucleic acid), revealed by American geneticist James Watson and British biophysicist Francis Crick in 1953—the famous double helix. The new understanding of the molecule that incorporates the genetic code provided an essential link between chemistry and biology, a bridge over which much traffic continues to flow. The individual “letters” that make the code—four nucleotides named adenine, guanine, cytosine, and thymine—were discovered a century ago, but only at the close of the 20th century could the sequence of these letters in the genes that make up DNA be determined en masse. In June 2000, representatives from the publicly funded U.S. Human Genome Project and from Celera Genomics, a private company in Rockville, Md., simultaneously announced the independent and nearly complete sequencing of the more than three billion nucleotides in the human genome. However, both groups emphasized that this monumental accomplishment was, in a broader perspective, only the end of a race to the starting line.

DNA is, of course, a macromolecule, and an understanding of this centrally important category of chemical compounds was a precondition for the events just described. Starch, cellulose, proteins, and rubber are other examples of natural macromolecules, or very large polymers. The word polymer (meaning “multiple parts”) was coined by Berzelius about 1830, but in the 19th century it was only applied to special cases such as ethylene (C2H4) versus butylene (C4H8). Only in the 1920s did the German chemist Hermann Staudinger definitely assert that complex carbohydrates and rubber had huge molecules. He coined the word macromolecule, viewing polymers as consisting of similar units joined head to tail by the hundreds and connected by ordinary chemical bonds.